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ＮＯ是由机体内多种细胞产生的一种多功能介质，作为内皮源性舒张因子及神经递质参与免疫防御、炎症和免疫介导的组织损伤。ＮＯ也是一种重要的生物信使，在抗肿瘤免疫及促肿瘤生长转移等方面具有双重作用［１］。ＴＮＦ－α主要由单核－巨噬细胞和内皮细胞产生，具有多种生物?
NO is a multifunctional mediator produced by a variety of cells in the body and functions as an endothelium-derived relaxing factor and neurotransmitter in immune defense, inflammation and immune-mediated tissue damage. NO is also an important biological messenger, which plays a dual role in anti-tumor immunity and tumor growth and metastasis [1]. TNF-α is mainly produced by monocytes - macrophages and endothelial cells, with a variety of biological?