论文部分内容阅读
子宫内膜异位症(endometriosis,EMS)是不孕症的常见病因,HOXA10、HOXA11这2种基因的正常表达与子宫内膜分泌中、晚期容受性的形成关系密切,而这2种基因在EMS患者的子宫内膜中与正常人相比表达下降,故EMS不孕的主要机制可能为低表达的HOXA10、HOXA11这2种基因,使子宫内膜的蜕膜化异常、容受性下降。此外,近期研究指出,导致EMS患者HOXA10、HOXA11基因表达下降的主要因素可能是基因异常甲基化。
Endometriosis (EMS) is a common cause of infertility. The normal expression of these two genes HOXA10 and HOXA11 is closely related to the formation of late and late tolerance of endometrial secretions. However, these two genes In EMS patients with endometrial expression decreased compared with normal, so the main mechanism of EMS infertility may be low expression of HOXA10, HOXA11 these two genes, the endometrial decidualization abnormalities, decreased tolerance . In addition, recent studies have pointed out that the main cause of HOXA10, HOXA11 gene expression in EMS patients may be the gene abnormal methylation.