论文部分内容阅读
目的探讨职业性暴露二甲基甲酰胺(DMF)工人的血清胃动素(MTL)、胃泌素(GAS)及血管活性肽(VIP)水平的变化和意义。方法 124名DMF作业工人作为暴露组,35名健康者作为对照组。暴露组按肝功能是否异常和自诉有无腹痛、腹胀症状分为肝损伤组32人、腹痛组30人和无症状暴露组62人。无症状暴露组按暴露DMF空气浓度再分为高浓度组32人和低浓度组30人。利用酶联免疫吸附法检测各组血清MTL、GAS和VIP水平。结果 DMF暴露者血清MTL、GAS和VIP水平要高于对照组,其中无症状高浓度组分别为(57.72±21.36)、(34.92±11.87)和(2.43±1.10)ng/L明显高于对照组的(42.89±19.32)、(25.10±9.62)和(16.28±7.74)ng/L(P<0.05);肝损伤组、腹痛组与其他各组比较差异均有统计学意义(P<0.01)。结论职业性DMF暴露与作业人群血清胃动素、胃泌素和血管活性肽水平升高相关。
Objective To investigate the changes and significance of serum motilin (MTL), gastrin (GAS) and vasoactive peptide (VIP) in workers exposed to dimethyl formamide (DMF). Methods 124 DMF workers as exposure group and 35 healthy persons as control group. According to whether the liver function was abnormal and whether there was abdominal pain or not in the exposed group, abdominal distension symptoms were divided into liver injury group (32), abdominal pain group (30) and asymptomatic exposure group (62). The asymptomatic exposure group was further divided into high concentration group of 32 and low concentration group of 30 by exposure to DMF. Serum MTL, GAS and VIP levels were detected by enzyme-linked immunosorbent assay. Results Serum levels of MTL, GAS and VIP in DMF exposed group were significantly higher than those in control group (57.72 ± 21.36), (34.92 ± 11.87) and (2.43 ± 1.10) ng / L, respectively, in asymptomatic high concentration group (42.89 ± 19.32), (25.10 ± 9.62) and (16.28 ± 7.74) ng / L, respectively (P <0.05). There was significant difference between the liver injury group and the abdominal pain group and other groups (P <0.01). Conclusions Occupational DMF exposure is associated with increased levels of serum motilin, gastrin and vasoactive peptide in the working population.