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Bcl 2、Bax是调控细胞凋亡的结构相似、作用相反的一对胞内蛋白质,二者的比例是决定对细胞抑制作用强弱的关键因素。Bcl 2 Bax与镉性肾细胞凋亡的发生、发展及转归密切相关。本文综述了Bcl 2、Bax调节细胞凋亡机制及在镉致肾细胞凋亡领域的研究进展。
Bcl 2 and Bax are a pair of intracellular proteins with similar structure and opposite function in the regulation of apoptosis. The ratio of Bcl 2 and Bax is the key factor that determines the effect on cell inhibition. Bcl 2 Bax is closely related to the occurrence, development and prognosis of cadmium-dependent renal cell apoptosis. This review summarizes the mechanisms by which Bcl 2 and Bax regulate cell apoptosis and the progress in the field of cadmium-induced renal cell apoptosis.