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目的 :观察小剂量米索前列醇 (米索 )直肠给药联合催产素预防高危产妇产后出血的临床效果。方法 :选择高危产妇4 2 1例 ,随机分为米索加催产素组 (米索组 ) 2 2 6例 ,催产素对照组 (对照组 ) 195例进行预防产后出血的观察。结果 :米索组和对照组 2 h出血量分别为 (172 .19± 72 .93) m l和 (30 4 .5 9± 2 15 .36 ) m l(P <0 .0 1)。米索组和对照组的产后出血率、出血休克率、产褥感染率和输血率情况比较 ,均有显著性差异 (P <0 .0 1)。米索组使用米索前、后 ,血压、脉搏无明显变化 (P >0 .0 5 )。未发现明显的毒副反应。结论 :小剂量米索直肠给药联合催产素预防产后出血具有疗效肯定、安全、快捷、持久和价廉等特点 ,特别适用于高危产妇作为预防产后出血时使用
Objective: To observe the clinical effect of low-dose misoprostol (misoprostol) rectal administration combined with oxytocin in preventing high-risk maternal postpartum hemorrhage. Methods: Forty-two high-risk mothers were selected and randomly divided into two groups: 226 cases of misoprostol (misoprostol group) and 195 cases of oxytocin control group (control group) for prevention of postpartum hemorrhage. Results: The amounts of bleeding in misoprostol and control groups were (172.19 ± 72.93) ml and (30.4.59 ± 2.15.36) ml (P <0.01), respectively. Misoprostol group and control group postpartum hemorrhage rate, hemorrhagic shock rate, puerperal infection rate and transfusion rate were significantly different (P <0.01). Before and after using misoprostol, there was no significant change in blood pressure and pulse (P> 0.05). No obvious side effects were found. Conclusion: The combination of small dose of misoprostol and oxytocin for the prevention of postpartum hemorrhage has certain curative effect, which is safe, quick, durable and cheap. It is especially suitable for high-risk maternal as a preventive measure against postpartum hemorrhage