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目的:比较乙肝五项不同模式之间,HBV-DNA与preS1结果的相关性。方法:同时对149份标本进行乙肝五项、HBV-DNA、preS1三项指标的检测,并对结果进行分析。结果:大三阳30例,HBV-DNA、preS1的阳性率分别为95.8%、68.4%;小三阳组58例,HBV-DNA、preS1的阳性率分别为59.1%、42.6%。1、5阳性25例,HBV-DNA、preS1的阳性率分别为75.2%、46.3%。HBsAg阴性36例,未检出HBV-DNA、preS1。结论:HBV-DNA、preS1、E抗原都能反映病毒复制情况,但preS1比E抗原更敏感,对于E抗原阴性的患者,preS1是一个判断HBV复制的有价值指标。
OBJECTIVE: To compare the correlation between HBV-DNA and preS1 in five different modes of HBV. Methods: At the same time, 149 samples were tested for five indexes of hepatitis B, HBV-DNA and preS1, and the results were analyzed. Results: The positive rates of HBV-DNA and preS1 were 95.8% and 68.4% respectively in 30 cases of Sanyang. The positive rates of HBV-DNA and preS1 were 59.1% and 42.6% respectively in 58 cases of Xiaosanyang group. The positive rates of HBV-DNA and preS1 in 25 cases were 75.2% and 46.3% respectively. 36 cases of negative HBsAg, HBV-DNA was not detected, preS1. CONCLUSIONS: HBV-DNA, preS1 and E antigens can reflect the replication of virus, but preS1 is more sensitive than E antigen. For patients with negative E antigen, preS1 is a valuable index for judging HBV replication.