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目的:研究紫茎女贞总苷对高脂血症大鼠血脂的影响。方法:建立高脂膳食诱导大鼠高脂血症模型,分别灌胃给予紫茎女贞总苷(1.2、0.6、0.3 g/kg)连续21 d。比色法测定血清总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白(LDL-C)含量;制作20%肝匀浆TBA比色法检测肝MDA含量。结果:紫茎女贞总苷可显著降低高脂血症大鼠血清TC、TG、LDL-C及肝脏MDA含量,且表现出一定的剂量-效应关系。紫茎女贞总苷降脂作用特点体现在能显著降低血清TG及肝MDA含量。结论:紫茎女贞是一种以降低血TG为特点的有效降血脂药物。
Objective: To study the effects of total rhizome of Pseudostellariae sinensis on blood lipids in hyperlipidemic rats. Methods: A rat model of hyperlipidemia induced by high-fat diet was established. Total adenosylmethionine (1.2, 0.6, 0.3 g / kg) was given intragastrically for 21 consecutive days. The contents of total cholesterol (TC), triglyceride (TG) and low density lipoprotein (LDL-C) in serum were determined by colorimetric method. TBA colorimetric method was used to detect the content of MDA in liver. Results: Total rhizome of Pseudostellariae Rhynchophylla could significantly reduce serum TC, TG, LDL-C and liver MDA content in hyperlipidemic rats, and showed some dose-effect relationship. Pseudostellariae total glycosides lipid-lowering effect is characterized by significant reduction in serum TG and liver MDA content. Conclusion: Prunus pseudostella is a kind of effective hypolipidemic drugs characterized by lowering blood TG.