目的　提高胰腺癌的根治性切除率。方法　对 16例胰腺癌施行扩大切除术 ,即以Whipple术或胰体尾部切除为基础 ,广泛清扫区域淋巴结 ,部分并受侵门静脉和 (或 )肠系膜上静脉 (PV/SMV)联合切除。结果　平均手术时间 8 5h。平均术中输血 12 5 0mL。 14例合并受侵PV/SMV联合切除。 11例 (6 8 8% )获根治性切除。术后发生并发症 7例 (4 3 8% )。围手术期死亡 1例 (6 2 5 % )。平均住院时间 35d。获根治性切除的 11例中 ,生存 1/ 2～ 1年者 2例 ,1～ 2年者 8例 ,1例已存活 32个月 ,无复发迹象。结论　胰腺癌的扩大切除术是安全可行的。单纯侵犯PV/SMV的胰腺癌仍有 2 / 3的可能获得根治性切除 Objective To improve the radical resection rate of pancreatic cancer. Methods 16 patients with pancreatic cancer underwent extended resection, which was based on Whipple surgery or pancreatic body tail resection. Regional lymph nodes were extensively dissected and partially resected by PV and SMV combined with portal vein and/or superior mesenteric vein. Results The average operation time was 85 hours. The average intraoperative blood transfusion was 1200 mL. In 14 cases, combined PV/SMV was removed. 11 cases (68.8%) were radically removed. Postoperative complications occurred in 7 patients (43%). Perioperative death occurred in 1 case (62.5%). The average hospital stay was 35 days. Of the 11 patients who had radical resection, 2 survived 1/2 to 1 year, 8 had 1 to 2 years, and 1 had survived for 32 months. There was no sign of recurrence. Conclusion Extended resection of pancreatic cancer is safe and feasible. Pancreatic cancer that simply invades PV/SMV is still 2/3 likely to have radical resection