转移因子(Transfer Factor “TF”)是从有免疫能力的供体淋巴细胞中提出的低分子量的肽与核苷酸的复合物,起着转移细胞免疫功能的作用,故是一种细胞介导的免疫调节剂。据近来报道多种动物如鼠、豚鼠、牛、绵羊、猴等的淋巴细胞中含有TF、并能在种间交叉转移免疫反应。我们在研制人脾转移因子(TF-h)基础上,进一步对猪脾转移因子(TF-p)进行了研究,并已成功地应用于临床作免疫治疗,本文报道TF-p的提取、理化性质及其生物活性。 Transfer Factor (“TF”) is a low-molecular-weight peptide-nucleotide complex that is raised from immunocompetent donor lymphocytes and plays a role in the transfer of cellular immune function. It is therefore a type of cell Mediated immune modulator. It has recently been reported that TFs are present in lymphocytes from a variety of animals such as mice, guinea pigs, cattle, sheep, and monkeys, and cross-species immune responses can be cross-speciesed. Based on the study of TF-h, we have further studied the TF-p in pigs and have been successfully used in clinical immunotherapy. We report the extraction, physicochemical Nature and its biological activity.