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目的：观察雷贝拉唑联合曲美布汀治疗功能性消化不良临床疗效。方法200例功能性消化不良患者随机分为两组，分别为观察组88例，对照组112例。两组患者均每日早餐前服用1次雷贝拉唑肠溶胶囊，20mg/次；观察组患者每日三餐后加服曲美布汀，0.1g/次,疗程2w。结果观察组上腹痛、上腹灼烧感、餐后饱胀症状改善情况明显优于对照组(<0.01)；嗳气症状改善情况无统计学意义(跃0.05)。对照组总有效率为74.1%；观察组总有效率为79.5%。两组均未出现明显不良反应。结论雷贝拉唑与曲美布汀联用可明显改善功能性消化不良的症状，且较为安全。“,”Objective To observe the curative ef ect of combined therapy of rabeprazole and trimebutin for functional dyspepsia. Methods 200 patients with functional dyspepsia were randomly grouped into observation group (n=88)and controls group (n=112).The patients in the two groups were given rabeprazole sodium enteric-coated capsules 20mg 1 times a day before breakfast for 2 weeks , The patients in the observation group were given trimebutin 0.1g 3 times a day after meals in addition to rabeprazole for 2 weeks.Results The symptoms of upper abdominal pain, stomach burn , abdominal distention after meals in the patients in the observation group were more improved than in the control group( <0.01) except for eructation.The total ef ective rate of the control group was 74.1%,The total ef ective rate of the observation group was79.5%,No severe untoward ef ects were found in the both groups.Conclusion Combined therapy of rabeprazole and trimebutin is safe and ef ective for improving symptoms in functional dyspepsia.