论文部分内容阅读
目的分析耐多药肺结核(MDR-TB)患者中断治疗的影响因素,为制定中断治疗的干预措施提供依据。方法采用病例对照研究方法,从浙江省2008年设立的5个项目市的病例中,分别选取已完成疗程并治愈和未完成疗程已中断治疗的MDR-TB患者各45例进行问卷调查,采用单因素分析和多因素Logistic回归分析MDR-TB患者中断治疗的影响因素。结果多因素Logistic回归分析结果显示,≥65岁(OR=8.69,95%CI:1.12~67.57)和有过停药或漏服药经历(OR=53.18,95%CI:5.90~479.27)是MDR-TB患者中断治疗的危险因素;住院治疗≥15 d(OR=0.09,95%CI:0.01~0.58)为保护因素。结论 MDR-TB患者中断治疗的原因主要与患者的年龄(≥65岁)、服药依从性差、住院时间短等有关。
Objective To analyze the influential factors of discontinuing treatment in patients with multidrug-resistant pulmonary tuberculosis (MDR-TB) and provide the basis for making interventions to interrupt the treatment. Methods A case-control study was conducted in 45 cases of MDR-TB patients who had completed the course of treatment and whose treatment courses were completed and those who did not finish treatment were selected from the 5 project cities established in Zhejiang Province in 2008. Factor analysis and multivariate Logistic regression analysis of factors affecting the discontinuation of MDR-TB patients. Results The results of multivariate Logistic regression analysis showed that patients aged ≥65 years (OR = 8.69, 95% CI: 1.12 to 67.57) and those with or without medication (OR = 53.18, 95% CI: 5.90 to 479.27) The risk factors of discontinuation in patients with TB were higher than that in hospitalized patients ≥15 days (OR = 0.09, 95% CI: 0.01-0.58). Conclusion The main reasons for discontinuation of MDR-TB patients are related to the patient’s age (≥65 years), poor medication compliance and short hospital stay.