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目的探讨补充钙质对中度铅中毒患儿的治疗效果和安全性。方法将符合入选标准、血铅水平在２００～４４９μｇ／Ｌ（１μｇ／Ｌ＝０．００４８３μｍｏｌ／Ｌ）的中度铅中毒患儿随机双盲方法分为实验组和对照组各３０例。结果无论是服钙剂组（实验组）的患儿还是服安慰剂组（对照组）的患儿，经过３个月的治疗，血铅水平均有明显下降。钙剂治疗组在治疗的３个月中血铅下降的幅度达７５μｇ／Ｌ，幅度远大于安慰剂组（３５μｇ／Ｌ），差异有极显著意义（Ｐ＜０．０１）。在治疗过程中，两组患儿均未出现肝肾功能异常，未出现高尿钙症及其他不良反应。结论补充钙剂对中度铅中毒患儿是有效和安全的方法。
Objective To investigate the therapeutic effect and safety of calcium supplementation on children with moderate lead poisoning. Methods A total of 30 children with moderate lead poisoning who had blood lead levels of 200 ~ 449μg / L (1μg / L = 0.00483μmol / L) were enrolled in the study. Results No significant difference was found in the levels of blood lead after three months of treatment in children taking calcium (experimental group) or placebo (control group). In the calcium treatment group, the blood lead level dropped by 75 μg / L within 3 months of treatment, which was much larger than that of the placebo group (35 μg / L). The difference was significant (P <0.01). In the course of treatment, both groups of children did not appear abnormal liver and kidney function, there is no high urinary calcium and other adverse reactions. Conclusion Calcium supplementation is an effective and safe method for children with moderate lead poisoning.