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目的探讨极低频电磁场对BALB/c鼠免疫功能影响。方法以BALB/c小鼠为研究对象,将小鼠暴露于极低频电磁辐射装置中,然后对其非特异性免疫功能,包括胸腺和脾脏指数、巨噬细胞吞噬指数指标进行测定。体液免疫功能的影响的检测是利用ELISA方法测量血清中抗体IgG的含量。结果本研究中1.0mT/、4.5 mT、9.0mT三个不同的照射剂量组与对照组比较而言,胸腺和脾脏在8周和12周低、中剂量的处理后,表现为胸腺脏器指数和脾脏指数的增加,但是高剂量组却表现为下降。对吞噬指数和体液免疫功能的影响也有类似的规律性。结论极低频电磁场对BALB/c小鼠免疫功能影响是在8周、12周时低、中剂量都表现为增强作用,高剂量暴露都是有抑制作用的。这一研究可以为制定电磁辐射对人类健康的标准提供有价值的数据。
Objective To investigate the effect of very low frequency electromagnetic field on immune function in BALB / c mice. Methods The BALB / c mice were exposed to a very low frequency electromagnetic radiation device. Then their nonspecific immune function including thymus and spleen index and macrophage phagocytic index were measured. The detection of the influence of humoral immune function is to measure the amount of antibody IgG in the serum by the ELISA method. Results Compared with the control group, the thymus and spleen of three different irradiation dose groups of 1.0mT /, 4.5mT and 9.0mT in this study showed thymus organ index And spleen index increased, but the high-dose group showed a decline. There is a similar pattern of effects on phagocytic index and humoral immune function. Conclusion The effect of ELF on the immune function of BALB / c mice was enhanced at low and medium doses at 8 and 12 weeks, and was inhibited by high dose exposure. This research can provide valuable data for setting the standard of human health for electromagnetic radiation.