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目的:探讨骨肽注射液穴位注射治疗老年骨质疏松症的临床疗效。方法:将90例老年骨质疏松症患者按随机数字表法分为治疗组、对照1组、对照2组,每组30例。治疗组穴位注射骨肽注射液加0.9%氯化钠注射液,对照1组肌内注射骨肽注射液,对照2组穴位注射0.9%氯化钠注射液。3组均隔天1次,共治疗3个月。观察两组治疗前后的症状评分、腰椎及髋部骨密度(BMD)、血清瘦素(Leptin)及胰岛素样生长因子Ⅰ(IGF-Ⅰ)的改善情况。结果:3组治疗后症状评分、血清Leptin均低于治疗前,腰椎及髋部BMD、血清IGF-Ⅰ均高于治疗前,组间比较,差异均有统计学意义(P<0.05);治疗后治疗组症状评分、BMD血清Leptin、IGF-I与对照1、2组比较,差异均有统计学意义(P<0.05)。结论:骨肽注射液穴位注射治疗老年骨质疏松症疗效确切,其机制可能与降低患者血清Leptin水平,提高血清IGF-Ⅰ水平有关。
Objective: To investigate the clinical effect of bone peptide injection acupoint injection in the treatment of senile osteoporosis. Methods: Ninety elderly patients with osteoporosis were randomly divided into treatment group, control group 1 and control group 2, with 30 cases in each group. The acupoint injection of bone peptide injection plus 0.9% sodium chloride injection in the treatment group, the control group 1 intramuscular injection of bone peptide injection, the control group 2 acupoint injection of 0.9% sodium chloride injection. 3 groups were every other day for a total of 3 months. The symptom scores, lumbar and hip BMD, serum leptin and insulin-like growth factor Ⅰ (IGF-Ⅰ) scores before and after treatment were observed. Results: After treatment, the symptom score, serum Leptin level were lower than before treatment, lumbar spine and hip BMD, serum IGF-Ⅰ were higher than before treatment, the difference between the two groups were statistically significant (P <0.05); treatment Post-treatment group symptom score, BMD serum Leptin, IGF-I compared with the control 1,2 group, the difference was statistically significant (P <0.05). Conclusion: The injection of bone peptide injection in the treatment of senile osteoporosis is effective and its mechanism may be related to the reduction of serum Leptin level and the increase of serum IGF-Ⅰ level.