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目的:探讨食管鳞癌患者血清CEA水平与临床病理因素关系的研究。方法:食管鳞癌患者281例,Ⅰ-Ⅲ期205例,Ⅳa期41例,Ⅳb期35例。以化学发光微粒子免疫分析法检测患者血清CEA水平,统计血清CEA水平与食管鳞癌分期之间的关系。收集Ⅰ-Ⅲ期患者性别、年龄、部位、肿瘤长度、脉管瘤栓、贲门受侵、组织学分级、淋巴结转移以及淋巴结转移数等临床病理资料,统计血清CEA水平与各临床病理参数之间的关系。采用χ2检验或Fisher精确检验法进行统计分析。结果:Ⅰ-Ⅲ期患者与ⅣA期患者血清CEA水平无显著性差异。但在Ⅰ-ⅣA期与ⅣB期患者组之间存在显著性差异。食管癌患者血清CEA水平与肿瘤的组织学分级以及淋巴结转移数有关,而与其他临床病理参数无关。结论:血清CEA检测对食管鳞癌临床诊治疗具有一定意义。
Objective: To investigate the relationship between serum CEA levels and clinicopathologic factors in patients with esophageal squamous cell carcinoma. Methods: There were 281 patients with esophageal squamous cell carcinoma, 205 patients in stage I-III, 41 patients in stage IVa, and 35 patients in stage IVb. Serum CEA levels were measured by chemiluminescent microparticle immunoassay and the relationship between serum CEA levels and esophageal squamous cell carcinoma staging was calculated. The clinicopathological data of stage I-III patients including gender, age, location, tumor length, vascular tumor embolus, cardiac invasion, histological grade, lymph node metastasis, lymph node metastasis, etc. were collected, and the serum CEA levels were compared with each clinicopathological parameter. Relationship. Χ2 test or Fisher’s exact test was used for statistical analysis. RESULTS: There was no significant difference in serum CEA levels between stage I-III and IVA patients. However, there was a significant difference between the I-IVA and IVB patient groups. Serum CEA levels in patients with esophageal cancer were related to the histological grade and number of lymph node metastases, but not to other clinicopathological parameters. Conclusion: Serum CEA has a certain significance in the clinical diagnosis and treatment of esophageal squamous cell carcinoma.