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目的:初步分析达英-35联合二甲双胍治疗多囊卵巢综合征(PCOS)的临床效果。方法:收治于新疆和田地区人民医院的140例PCOS伴有胰岛素抵抗(IR)不孕患者,随机分为对照组和观察组。对照组70例,单独应用达英-35治疗;观察组70例,应用达英-35联合二甲双胍治疗。治疗3个疗程后观察2组患者促排卵效果。结果:2组患者治疗后,观察组患者黄体生成素(LH)、促卵泡素(FSH)、睾酮(T),以及HOMA-IR明显降低。同时治疗后,观察组TC和TG都低于对照组(P<0.05),差异显著。结论:PCOS伴有IR不孕患者应用达英-35联合二甲双胍治疗,可明显改善内分泌失控状态,在此基础上可促进排卵,提高妊娠率。
OBJECTIVE: To analyze the clinical effect of combination of da-Ying-35 and metformin in the treatment of polycystic ovary syndrome (PCOS). Methods: One hundred and forty cases of PCOS patients with insulin resistance (IR) infertility who were admitted to the People’s Hospital of Hotan, Xinjiang were randomly divided into control group and observation group. The control group, 70 cases were treated with up to Ying -35 alone; the observation group of 70 cases, the application of Ying-35 combined with metformin treatment. After 3 courses of treatment, the ovulation promoting effect of 2 groups was observed. Results: After treatment, the LH, FSH, T and HOMA-IR of the observation group were significantly decreased. After treatment, TC and TG in the observation group were lower than those in the control group (P <0.05), the difference was significant. Conclusion: The combination of Tamoxifen and metformin in patients with PCOS associated with IR infertility can significantly improve the state of endocrine uncontrollability. On the basis of this, it can promote ovulation and improve the pregnancy rate.