二膦酸盐是近年来研发的抗代谢性骨病的一类新药,其可以抑制破骨细胞介导的骨质破坏。文中综述了二膦酸盐治疗肿瘤的研究进展。其中有研究表明二膦酸盐有直接的抗肿瘤作用,包括抑制肿瘤细胞增殖,促进肿瘤细胞凋亡;减少肿瘤细胞的黏附性及侵袭性。同时有研究证实二膦酸盐尚有抑制肿瘤血管生成、调节免疫等间接抗肿瘤作用。此外,二膦酸盐与其他化疗药物或T细胞联合应用可以达到协同抗肿瘤效果。这些新发现显示二膦酸盐可能被作为一种抗肿瘤药物应用于临床。 Bisphosphonates, a new class of antimetabolic osteodystrophy developed in recent years, inhibit osteoclast-mediated destruction of bone. The article reviewed the research progress of bisphosphonates in the treatment of tumors. Studies have shown that bisphosphonates have a direct anti-tumor effect, including inhibition of tumor cell proliferation, promote tumor cell apoptosis; reduce tumor cell adhesion and invasiveness. At the same time, studies have confirmed that bisphosphonates still inhibit tumor angiogenesis, immune and other indirect anti-tumor effect. In addition, bisphosphonates and other chemotherapeutic drugs or T cells in combination can achieve synergistic anti-tumor effect. These new findings show that bisphosphonates may be used clinically as an antineoplastic drug.