目的总结胰腺血管活性肠肽瘤(VIPoma)的临床特点并探讨其诊治方法。方法回顾性分析1991年11月至2010年2月期间我院收治的3例VIPoma患者的临床资料。结果 3例均有周期性发作水样泻、低钾血症和低或无胃酸。有2例血浆血管活性肠肽值显著升高。B超及CT发现3例肿瘤均位于胰腺内,其中1例肝转移,1例怀疑肝转移。3例均行手术治疗。1例肿瘤位于胰头部行胰十二指肠切除术,随访3年无肿瘤复发;1例肿瘤位于胰头颈部及肝脏多发转移灶,行胰腺头颈部切除及肝脏转移结节摘除术,术后4个月腹泻症状复发,证实肝脏多发转移灶,又先后3次手术,于第1次手术后3.5年死于电解质紊乱;另1例术中发现肿瘤位于胰头部无法切除,肝脏多发转移灶,摘除1枚肝脏结节病理确认为转移癌,术后间断应用奥曲肽,术后2.5年仍在随访中。结论 VIPoma首选的治疗方法是手术切除肿瘤。恶性肿瘤即使无法根治手术,也应该姑息性切除和间断应用奥曲肽,以改善患者生活质量。 Objective To summarize the clinical features of VIPoma and explore its diagnosis and treatment. Methods The clinical data of 3 patients with VIPoma treated in our hospital from November 1991 to February 2010 were retrospectively analyzed. Results All the 3 patients had periodic episodes of watery diarrhea, hypokalemia and low or no gastric acid. 2 cases of plasma vasoactive intestinal peptide value was significantly increased. B ultrasound and CT found that 3 cases of tumors were located in the pancreas, of which 1 case of liver metastases, 1 case of suspected liver metastases. 3 patients underwent surgical treatment. One patient had pancreatic head and pancreaticoduodenectomy and had no tumor recurrence during the follow-up period of 3 years. One patient had multiple metastatic lesions in the pancreas and neck and the liver. The pancreatic head and neck resection and hepatic metastasis nodules removal , 4 months after the recurrence of diarrhea symptoms, multiple liver metastases confirmed, but also three times in the first surgery 3.5 years after the death of electrolyte imbalance; the other 1 case was found in the tumor in the head of the pancreas can not be removed, the liver Multiple metastases, removal of a liver nodule pathology confirmed as metastatic cancer, intermittent application of octreotide after surgery, 2.5 years after follow-up. Conclusion The preferred treatment for VIPoma is surgical removal of the tumor. Malignant tumors should be treated with palliative excision and intermittent administration of octreotide to improve patient quality of life, even if the procedure is not curable.