目的 :观察国产克拉霉素的短程三联疗法根除幽门螺杆菌 (Hp)感染的疗效及不良反应。方法 :91例Hp阳性的消化性溃疡或糜烂性胃窦炎病人 ,分为A组 ( 4 7例 ,男性 4 0例 ,女性 7例 ,年龄 57a±s14a)和B组 ( 4 4例 ,男性 4 0例 ,女性 4例 ,年龄59a± 15a)。A组以奥美拉唑 2 0mg、替硝唑 50 0mg及国产克拉霉素 2 50mg ,po ,bid ;B组治疗同A组 ,只是将国产克拉霉素改为进口克拉霉素 ,疗程均为 7d。疗程结束 1mo后复查胃镜及Hp。结果 :A ,B 2组Hp根除率分别为 85%和 91% ,不良反应发生率分别为 11%和 14% ,但均能耐受 ,2组比较差异无显著意义 ,P >0 .0 5。每例抗Hp费用A组为 4 70元、B组 550元。结论 :A ,B 2组疗效相近 ,均无严重不良反应 ,但A组费用较低 ,提示国产克拉霉素可替代进口克拉霉素用于Hp根除 Objective: To observe the efficacy and side effects of short-range triple therapy with domestic clarithromycin in the eradication of Helicobacter pylori (Hp) infection. Methods: A total of 91 Hp-positive patients with peptic ulcer or erosive antral gastritis were divided into group A (47 cases, 40 males, 7 females, age 57a ± s14a) and group B (44 males 40 cases, 4 females, age 59a ± 15a). A group of omeprazole 20mg, tinidazole 50mg and domestic clarithromycin 2 50mg, po, bid; B group with the treatment of A group, but the domestic clarithromycin imported clarithromycin, treatment were 7d. After the end of 1mo review endoscopy and Hp. Results: The Hp eradication rates in groups A and B 2 were 85% and 91%, respectively, and the incidences of adverse reactions were 11% and 14%, respectively, but both were tolerable. There was no significant difference between the two groups (P> 0.05) . Each anti-Hp cost A group of 4 70 yuan, B group of 550 yuan. Conclusion: The efficacy of group A and B 2 are similar with no serious adverse reactions, but the cost of group A is lower, which suggests that domestic clarithromycin can replace imported clarithromycin for Hp eradication