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Introduction Since the isolation and discovery of the potent anticancer properties of dauno-mycin(daurorubicin)and adriamycin,the study of anthracycline antitumor an-tibiotics became one of the most active research topics in the area of new anticancer chemotherapeutic agents.Of the large number of daunomycin and adriamycinderivatives,majority of them displayed low activity or extremely high toxicity orinstability.Several second generation anthracycline analogues both of naturaland synthetic origin,such as 4-demethoxy—daunomycin,——adriamycin,——4’-deoxyadriamycin,——adriamycin,——11-deoxydaunomycin,11-deoxydaunomycin,4’-epiadriamycin,aclacinomycin A and B etc.are in various phases of clinical
Introduction Since the isolation and discovery of the potent anticancer properties of dauno-mycin (daurorubicin) and adriamycin, the study of anthracycline antitumor an-tibiotics became one of the most active research topics in the area of new anticancer chemotherapeutic agents. Of the large number of daunomycin and adriamycinderivatives, majority of them displayed low activity or extremely high toxicity orinstability. Subject second generation anthracycline analogues both of naturaland synthetic origin, such as 4-demethoxy-daunomycin, - adriamycin, - 4’-deoxyadriamycin, - adriamycin , - 11-deoxydaunomycin, 11-deoxydaunomycin, 4’-epiadriamycin, aclacinomycin A and B etc.are in various phases of clinical