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性分化异常原因复杂,包括遗传性和非遗传性因素。下面就性分化异常原因作一简单介绍。1 非遗传因素1.1 外环境因素影响妊娠期间孕妇服用雄激素,口服保胎药,以及孕妇患肾上腺或卵巢肿瘤疾病等,可引起(44+XX)女性胎儿外生殖器男性化或第二性征男性化。人工合成化学污染物能干扰机体正常内分泌功能,该类物质与雄性性分化异常有关,称之为环境雌激素。环境雌激素可通过不同途径影响间质细胞功能,减少睾酮生物合成,从而干扰雄性性发育的各个环节。环境雌激素包括人工合成的雌激素(如己烯雌酚 DEs、17-β-雌二醇等)、杀虫剂(如 DDT、甲氧氯、乐果等)和工业污染物(如多氯联苯、烷基酚、双酚 A
The causes of abnormal sexual differentiation are complex, including hereditary and non-hereditary factors. The following is a brief introduction to the causes of abnormal sexual differentiation. 1 Non-genetic factors 1.1 External environmental factors affect pregnant women taking androgens during pregnancy, oral fetal protection drugs, and pregnant women suffering from adrenal or ovarian tumor disease, can cause (44 + XX) female fetal genitalia masculinity or secondary sexual characteristics of men Change. Artificial synthetic chemical pollutants can interfere with the normal endocrine function of the body. This type of substance is associated with abnormal male sexual differentiation and is called environmental estrogen. Environmental estrogen can affect interstitial cell function and reduce testosterone biosynthesis through different pathways, thereby interfering all aspects of male sexual development. Environmental estrogens include synthetic estrogens (such as diethylstilbestrol DEs, 17-β-estradiol, etc.), insecticides (such as DDT, methoxychlor, dimethoate, etc.), and industrial pollutants (such as PCBs, Alkylphenol, bisphenol A