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目的 :观察和评价比索洛尔临床疗效和耐受性。方法 :共收入轻、中度原发性高血压患者(舒张压 95至 115 mm Hg) 2 9例 ,经停用其他降压药物 1周后给予比索洛尔 5～ 10 mg每日 1次治疗 ,每周测量血压及心率并记录不良反应 ,进行相关体检。其中 8例于治疗前后分别进行了 2 4h动态血压监测 ,10例接受了心率变异性的测定。结果 :经 8周治疗 ,患者的收缩压 /舒张压平均下降了 ( 18.4±9.5 ) / ( 13.4± 6.1) mm Hg,与治疗前比较差异有显著性 ( P <0 .0 5 ) ,总有效率为 82 .8% ,心率平均下降 12 .4次 / min。不良反应少且多为轻度头晕、乏力及胸闷等。动态血压监测显示 2 4h平均收缩压/舒张压较治疗前下降了 17.5 / 12 .2 mm Hg,谷峰比值分别为 5 9.7%和 69.2 % ,R- R间期标准差平均增加 2 2 ms。结论 :比索洛尔每日 1次可有效控制血压 ,耐受性好
Objective: To observe and evaluate the clinical efficacy and tolerability of bisoprolol. Methods: A total of 29 patients with mild or moderate essential hypertension (DBH 95-115 mm Hg) were enrolled. After one-week discontinuation of other antihypertensive drugs, bisoprolol 5-10 mg once daily was given , Weekly measurement of blood pressure and heart rate and record adverse reactions, the relevant physical examination. Eight of them were monitored for ambulatory blood pressure 24 hours before and after treatment, and 10 cases were tested for heart rate variability. Results: After 8 weeks of treatment, the systolic pressure / diastolic pressure decreased by (18.4 ± 9.5) / (13.4 ± 6.1) mm Hg on average, which was significantly different from that before treatment (P <0.05) Efficiency was 82.8%, heart rate decreased by an average of 12.4 times / min. Less adverse reactions and mostly mild dizziness, fatigue and chest tightness and so on. Ambulatory blood pressure monitoring showed a mean systolic / diastolic blood pressure of 24.5h, a 17.5 / 12.2mm Hg decrease compared with that before treatment, with a peak-to-valley ratio of 57.7% and 69.2%, respectively, and an average increase in standard deviation of R-R intervals of 22ms. Conclusion: Bisoprolol once daily can effectively control blood pressure and is well tolerated