根据我国部分地区肿瘤普查材料,大肠癌发病率为3.1—10.7/10万,占癌症的第6—9位。深入了解大肠癌的病因,发病规律,致癌因素以及病变过程中代谢(组织酶活性)的改变对建立新的早期诊断方法,采取有效的预防措施和改进治疗手段等均有着重要意义。下面着重介绍国外近几年来在大肠癌致病因素方面的研究进展,以供参考。打开大肠癌地理分布的“世界地图”一看,我们就会发现它在一些经济发达的地区,如北美(美国,加拿大),西北欧(英国、丹麦)和澳大利亚流行最甚;在亚洲(日本,印度),非洲(莫三鼻给,乌干达),中南美(阿根廷,乌拉圭除外)则较为少见。从大肠癌 According to the general survey of tumors in some parts of China, the incidence of colorectal cancer is 3.1-10.7/10 million, accounting for 6-9 of cancer. A thorough understanding of the etiology, pathogenesis, and carcinogenic factors of colorectal cancer and changes in metabolism (tissue enzyme activity) during the process of the disease are of great significance in establishing new early diagnosis methods, adopting effective preventive measures and improving treatment methods. The following focuses on the research progress of foreign countries in recent years in the pathogenesis of colorectal cancer, for reference. Looking at the “World Map” of geographical distribution of colorectal cancer, we will find that it is most popular in some economically developed regions such as North America (USA, Canada), Northwest Europe (UK, Denmark) and Australia; in Asia (Japan (India), Africa (Mosanguchi, Uganda), Central and South America (Argentina, Uruguay, except) are less common. From colorectal cancer