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苯妥英(PHT)是一种廉价抗惊厥药,但对学习和记忆功能有不良影响。假马齿苋Bacopa monniera 遍及印度潮湿和沼泽地带,大量研究证实其有益智作用并具有很好的耐受性而无不良反应。作者研究了该植物单用及与 PHT 合用对小鼠被动回避(PA)反应、最大电休克诱导的惊厥(MES)及运动能力(LA)的影响。该植物乙醇提取物干浸膏(BM)以1%阿拉伯胶溶液制成混悬液。实验采用 Swiss小鼠。PHT 单用时剂量为25 mg/kg,服用14
Phenytoin (PHT) is a cheap anticonvulsant but has adverse effects on learning and memory functions. The False Purslane, Bacopa monniera, is found throughout the humid and swampy regions of India. A large number of studies have demonstrated that it is sensible and has good tolerance without adverse reactions. The authors studied the effect of the plant alone and in combination with PHT on the passive avoidance (PA) response, maximal electroshock induced seizures (MES), and exercise capacity (LA) in mice. The plant ethanol extract dry extract (BM) was made into a suspension with a 1% gum arabic solution. The experiment used Swiss mice. PHT alone dose 25 mg/kg, taking 14