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子宫内膜间质肉瘤占子宫恶性肿瘤的1%,占子宫恶性间叶肿瘤的15%。WHO(2014)生殖肿瘤分类将子宫内膜间质肉瘤分为低级别子宫内膜间质肉瘤、高级别子宫内膜间质肉瘤及未分化子宫肉瘤。子宫内膜间质肉瘤常因频发染色体易位,致使发生参与表观遗传调控相关的基因融合。迄今为止,仅发现Y WHAE-NUTM2重排与明确的高级别形态学及侵袭性临床行为密切相关。具有YWHAE重排的高级别子宫内膜间质肉瘤预后介于低级别子宫内膜间质肉瘤与未
Endometrial stromal sarcoma accounts for 1% of uterine malignancies, accounting for 15% of malignant mesenchymal tumors. WHO (2014) Classification of Reproductive Neoplasms Endometrial stromal sarcoma is divided into low-grade endometrial stromal sarcoma, high-grade endometrial stromal sarcoma and undifferentiated uterine sarcoma. Endometrial stromal sarcoma often due to frequent chromosomal translocations, resulting in the occurrence of epigenetic regulation involved in gene fusion. To date, only Y WHAE-NUTM2 rearrangements have been found to be closely associated with definite high-grade morphological and invasive clinical behaviors. The prognosis of high-grade endometrial stromal sarcoma with YWHAE rearrangement is between that of low-grade endometrial stromal sarcoma