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应用靶向剂LHSA交联“425”制剂，经腹腔注入感染日本血吸虫尾蚴后4周的BALB／c小鼠，每鼠0．5ml／d（内含“425”制剂10mg）。连续用药2周（相当于感染后6周）后，肝内虫卵肉芽肿平均直径与感染对照组相比，下降了39．93％，平均面积下降了62．37％；平均体积下降了79．01％。停药1～2周（相当于感染后7～8周）时，平均直径、面积和体积分别下降了34．04％～40．24％，59．00％～65．92％和74．79％～77．23％。结果表明，LHSA交联“425”制剂具有明显的抗日本血吸虫卵肝内肉芽肿病变的效果。
BALB / c mice infected with S. japonicum cercariae at 4 weeks were intraperitoneally injected with “425” formulation with the targeting agent LHSA, 0.5 ml / d per mouse (containing “425 mg of formulation” 10 mg). After 2 weeks continuous treatment (equivalent to 6 weeks after infection), the average diameter of intrahepatic egg granulomas decreased by 39.93% and the average area decreased by 62.37% compared with the control group; the average volume decreased by 79% .01%. After stopping for 1 to 2 weeks (equivalent to 7 to 8 weeks after infection), the average diameter, area and volume decreased by 34.04% -40.24%, 59.00% -65.92% and 74.79 % ~ 77.23%. The results showed that the LHSA cross-linked “425” formulation has obvious anti-Schistosoma japonicum intrahepatic granuloma lesions.