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血管内皮生长因子(VEGF)是一种序列高度保守、高度特异性的促血管内皮细胞生长因子,广泛分布于人和动物体内的大脑、肾脏、肝脏、脾脏、胰腺和骨骼等组织中,对内皮细胞具有强烈的促有丝分裂作用,刺激血管内皮细胞增殖和血管通透性增加,促进新生血管形成。VEGF通过与血管内皮细胞表面受体(VEGFR)特异性结合发挥生物学效应。抑制VEGF及VEGFR的活性可以减缓或阻滞骨肉瘤侵袭和转移。研究表明,VEGF及VEGFR对肿瘤血管及淋巴管的生成及肿瘤侵袭和转移起重要作用。本文对VEGF及VEGFR与骨肉瘤血管与淋巴管生成及其侵袭与转移的关系作一综述。
Vascular endothelial growth factor (VEGF) is a highly conserved and highly specific vascular endothelial growth factor. It is widely distributed in brain, kidney, liver, spleen, pancreas and bone in humans and animals, Cells have a strong mitogenic effect, stimulate vascular endothelial cell proliferation and vascular permeability increased, and promote angiogenesis. VEGF exerts a biological effect by specifically binding to the vascular endothelial cell surface receptor (VEGFR). Inhibition of VEGF and VEGFR activity can slow or block the invasion and metastasis of osteosarcoma. Studies have shown that VEGF and VEGFR play an important role in tumor vessel and lymphangiogenesis and tumor invasion and metastasis. This review summarizes the relationship between VEGF and VEGFR and the angiogenesis, lymphangiogenesis and invasion and metastasis of osteosarcoma.