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造血干细胞(hematopoietic stem cell,HSC)具有自我更新功能和生成多个系列免疫造血细胞的多分化功能,终生维持机体造血。证据显示HSC会出现衰老,并与机体老龄化及各种损伤情况下出现造血系统应激能力下降有关。DNA损伤反应在诱导HSC衰老的各种机制中起重要作用。HSC发生衰老的机制的研究将对降低放化疗毒副作用,保护辐射等环境因素的损伤,了解白血病的干细胞起源及治疗逃逸机制提供有价值的科研资料,为药物筛选的靶点提供试验依据。
Hematopoietic stem cells (HSC) have the function of self-renewal and multi-differentiation to generate multiple series of hematopoietic hematopoietic cells and maintain the body’s hematopoiesis for the rest of his life. Evidence shows that HSC can develop senescence and is associated with a decline in the ability of the hematopoietic system to respond to stress as it ages and under various conditions of injury. DNA damage response plays an important role in various mechanisms of inducing HSC senescence. The mechanism of HSC aging will provide valuable scientific research materials for reducing the side effects of radiotherapy and chemotherapy, protecting the damage of radiation and other environmental factors, understanding the stem cell origin of leukemia and treating escape mechanism, and providing experimental basis for drug screening target.