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目的:为了安全用药,对冰片制剂口服给药的安全性进行研究。方法:将冰片用水溶性辅料聚乙二醇6000制成固体分散体,并填装入胶囊,进行毒理试验。结果:口服急毒、长毒试验及腹腔注射给药试验表明,冰片固体分散体安全。结论:本试验将为冰片在中药复方制剂中的安全应用提供依据。
Objective: To study the safety of oral administration of borneol preparations for safe drug use. Methods: The borneol was made into a solid dispersion with water-soluble excipient polyethylene glycol 6000 and filled into capsules for toxicity testing. RESULTS: Oral acute toxicity, long toxicity test and intraperitoneal injection test showed that the borneol solid dispersion was safe. Conclusion: This experiment will provide the basis for the safe application of Borneol in traditional Chinese medicine compound preparations.