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目的:研究血小板反应素(Thrombospondin,TSP)、微血管标记的微血管密度(microvessel density,MVD)、erbB4蛋白3项指标在维吾尔族和汉族乳腺浸润性导管癌的表达差异。方法:收集14例维吾尔族和31例汉族乳腺浸润性导管癌(IDC)外科手术标本,采用免疫组化SP法检测TSP、MVD、erbB4蛋白表达。结果:维、汉族IDC中TSP、MVD阳性表达率差异无统计学意义(P>0.05);erbB4蛋白阳性表达率差异有统计学意义(P<0.05)。结论:erbB4基因可能促进汉族乳腺浸润性导管癌的发生、发展,具有种族特异性。但TSP、MVD表达在汉族和维吾尔族中不具有差异。
Objective: To investigate the difference of expression of Thrombospondin (TSP), microvessel density (MVD) and erbB4 in infiltrating ductal carcinoma between Uighur and Han nationality. Methods: Fourteen Uygur and 31 cases of invasive ductal carcinoma of the breast (IDC) were collected. The expressions of TSP, MVD and erbB4 protein were detected by immunohistochemical SP method. Results: The positive rates of TSP and MVD in Uygur and Han nationality IDC were not significantly different (P> 0.05). The positive rates of erbB4 protein expression had statistical significance (P <0.05). Conclusion: The erbB4 gene may promote the occurrence and development of invasive ductal carcinoma of the breast in Han ethnicity. It is racially specific. However, TSP and MVD expression did not differ between Han and Uygur ethnic groups.