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目的观察研究吸入麻醉药七氟醚对儿童高级神经活动学习、记忆功能的影响。方法选择7~10岁男生择期下腹部手术33例,分为七氟醚组(20例)和对照组(13例)。采用“韦氏记忆量表”进行学习记忆能力的测试,测试术前、术后1d、术后1周长时记忆、短时记忆及瞬时记忆的量表得分。结果①七氟醚组和对照组2组术后1d与术前、术后1周相比,短时记忆量表得分均显著下降,差异有显著性(P<0.05);②术后1周2组患儿的短时记忆量表得分均已经接近原来的水平;③术后1d短时记忆量表得分七氟醚组与对照组量表得分相近,差异没有显著性意义。结论①手术患儿学习记忆能力的改变,术后1 d在短时记忆的分测验中有明显的下降,而对长时记忆和瞬时记忆没有明显改变;②未能提示吸入麻醉药七氟醚对儿童学习记忆能力的影响是一个独立的风险因素。
Objective To study the effects of inhaled anesthetic sevoflurane on advanced neural activity and memory in children. Methods Thirty-three boys undergoing elective abdominal surgery from 7 to 10 years old were selected and divided into sevoflurane group (n = 20) and control group (n = 13). The Wechsler memory scale was used to test the learning and memory ability. The scores of memory, short-term memory and instant memory were measured before operation, 1 day after operation and 1 week after operation. Results ① Compared with preoperative and postoperative one week, the scores of short-term memory scale in sevoflurane group and control group were significantly decreased on the 1st day after operation (P <0.05); ② One week after operation Short-term memory scale score of the two groups of children were close to the original level; ③ score of short-term memory 1d after operation was similar between the sevoflurane group and the control group, the difference was not significant. Conclusion ① The change of learning and memory abilities in children with surgery showed a significant decrease in short-term memory sub-test 1 d after surgery, but no significant change in long-term memory and transient memory; ② Failure to prompt inhalation anesthetic sevoflurane The impact on children’s learning ability is an independent risk factor.