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目的 :观察虎杖大黄素在活体中抗Ⅰ型人疱疹病毒作用。方法 :以阿昔洛韦 (ACV )为阳性对照 ,以含 1.0ml/LTween 80的PBS及PBS为阴性对照 ,用HSV 1HS 1株感染豚鼠皮肤复制动物模型 ,观察虎杖大黄素抗Ⅰ型人疱疹病毒的药效。结果 :ACV及虎杖大黄素处理皮区的累积计分依次为 (14 .2 0± 6 .70 )分 ,(7.0 0± 6 .16 )分 ;ACV及虎杖大黄素处理皮区的痊愈时间分别为 (7.2 0± 1.0 8)d ,(6 .30± 1.4 0 )d ,与PBS及含 1.0ml/LTween 80的PBS处理皮区有明显的差异 ,且与皮肤样本的病毒滴度检测结果相一致。结论 :虎杖大黄素比ACV治疗豚鼠皮肤Ⅰ型人疱疹病毒感染的效果好 ,值得开发利用
Objective : To observe the effect of Polygonum cuspidatum against type I human herpesvirus in vivo. METHODS: Acyclovir (ACV) was used as positive control, PBS containing 1.0 ml/L Tween 80 and PBS were used as negative controls, and HSV 1HS 1 strain was used to infect guinea pig skin replication animal model to observe the anti-I type human herpes The efficacy of the virus. Results: The accumulative scores of ACV and Polygonum cuspidatum treated areas were (14.20 ± 6.70) points, (7.0 0 ± 6.16) points; the healing time of ACV and Polygonum cuspidatum emodin treatment areas were respectively (7.20±1.08)d, (6.30±1.40)d, significantly different from that of PBS and PBS treated with 1.0 ml/L Tween 80, and compared with the results of virus titer test of skin samples. Consistent. Conclusion : Polygonum cuspidatum emodin is more effective than ACV in the treatment of type I human herpesvirus infection in guinea pig skin and is worth exploitation and utilization.