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Minoxidil(6-氨基-1,2二氢-1-羟基-2亚氨基-4哌啶基嘧啶)是一种新的具有强力降压作用的血管扩张药。其药理作用看来系直接作用于血管壁,对中枢神经系统、肾上腺素能或组织胺能受体不起作用。Minoxidil治疗高血压有良好的效果且无严重副作用。本文报道9例高血压不能为现有常用药物控制的高血压尿毒症患者加用Minoxidil治疗的结果。 9例患者除1例外,均因末期肾病而作间歇血液透析治疗,平均已有9个半月。导致肾衰竭的病因为:慢性肾小球性肾炎2例,恶性高血压4例,慢性肾硬化症3例。卧位血压为200±6/124±3毫米汞柱。眼底为Ⅲ～
Minoxidil (6-Amino-1,2-dihydro-1-hydroxy-2-imino-4-piperidinopyrimidine) is a novel vasodilator with potent antihypertensive effect. Its pharmacological effects appear to act directly on the vessel wall with no effect on the central nervous system, adrenergic or histaminergic receptors. Minoxidil is effective in treating high blood pressure without serious side effects. This article reports 9 cases of hypertension can not be used for existing commonly used drugs in patients with hypertensive uremia plus Minoxidil treatment results. All but one of the nine patients were treated for intermittent hemodialysis because of end-stage renal disease, an average of nine and a half months. The causes of renal failure are: 2 cases of chronic glomerulonephritis, 4 cases of malignant hypertension, 3 cases of chronic nephrosclerosis. Blood pressure in the supine position was 200 ± 6/124 ± 3 mmHg. Fundus Ⅲ ~