由于甲状腺髓样癌具有特征性的组织形态,显示各种内分泌异常、家族倾向性及合并症等,成为引入注目的肿瘤。本瘤在欧美曰趋增多,但在日本到1978年为止共报告100例,其中在同一家族中有二人同时患MEN—Ⅱ型病变者仅有7例,国内尚未见报告。现将本院所见兄妹二人均患有MEN—Ⅱ型病例报告如下。 Because medullary thyroid carcinoma has a characteristic histomorphology, it shows a variety of endocrine abnormalities, familial tendencies, comorbidities, and the like, and has become an attractive tumor. The tumor has been increasing in Europe and the United States. However, 100 cases were reported in Japan from 1978 to the end of the year. Among them, only 7 cases of MEN-II disease in the same family were reported. There have been no reports in the country. The two brothers and sisters in this hospital are reported to have MEN-II cases as follows.