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目的：了解大剂量山莨菪碱及地塞米松对多脏器功能失常综合征兔微循环变化的影响。方法：将日本大耳兔行盲肠结扎加穿孔（ＣＬＰ）术，造成腹腔感染致多器官功能障碍的动物模型，其中实验组和对照组各１１只，应用瑞典ＰＥＲＩＭＥＤ公司的新型４００１双通道激光多普勒血流仪动态测定应用大剂量山莨菪碱（３ｍｇ／ｋｇ）及地塞米松（１０ｍｇ／ｋｇ）时兔耳及大腿肌肉内微循环的变化。结果：对照组静注生理盐水后大腿肌肉内微循环的灌注量由（３２６．１５±８７．３２）ＰＵ增加到（６５６．７８±１０２．５０）ＰＵ，兔耳微循环的灌注量由（８．５０±１．８５）ＰＵ增加到（１１．４９±３．４２）ＰＵ。实验组静注大剂量山莨菪碱及地塞米松后大腿肌肉内微循环的灌注量由（２９０．５０±２０．１８）ＰＵ增加到（６９１．３９±１０２．０７）ＰＵ，兔耳微循环的灌注量由（５．３６±３．２６）ＰＵ增加到（１９．７８±１０．１０）ＰＵ。结论：静注大剂量山莨菪碱及地塞米松能明显改善兔在多器官功能障碍时微循环的灌注，对保护和维持重要脏器的功能十分有利。
Objective: To investigate the effects of high-dose anisodamine and dexamethasone on microcirculation in rabbits with multiple organ dysfunction syndrome. Methods: The cecal ligation and perforation (CLP) were performed on Japanese eared rabbits, which caused multiple organ dysfunction caused by intraperitoneal infection. The experimental group and the control group were each 11 rats. The new 4001 dual-channel laser of PERIMED company Doppler flowmetry was used to measure the changes of the microcirculation in the rabbit ears and thigh when high dose of anisodamine (3mg / kg) and dexamethasone (10mg / kg) were applied. Results: The perfusion of microcirculation in the thigh muscle increased from (326.15 ± 87.32) PU to (656.78 ± 102.50) PU in the control group after intravenous injection of saline, 8.50 ± 1.85) PU increased to (11.49 ± 3.42) PU. In experimental group, the perfusion of microcirculation in the thigh muscles after high dose of anisodamine and dexamethasone was increased from (290.50 ± 20.18) PU to (691.39 ± 102.07) PU, and the rabbit ear microcirculation The perfusion increased from (5.36 ± 3.26) PU to (19.78 ± 10.10) PU. Conclusion: Intravenous injection of anisodamine and dexamethasone can significantly improve the perfusion of microcirculation in multiple organ dysfunction, which is very beneficial for the protection and maintenance of the function of vital organs.