论文部分内容阅读
动脉粥样硬化是一种严重危害人类健康的疾病,血管平滑肌细胞的增殖与凋亡在其病理生理过程中起核心作用,根本上受各种原癌基因的调控,C-myc在其中发挥了不可替代的双重功能,它影响和调控细胞的生长、增殖、分化、凋亡和细胞周期的进程,同时对自身的基因表达和其他细胞内基因表达也有重要的调节作用。研究C-myc对血管平滑肌细胞增殖与凋亡的影响及其机制,可为彻底阐明动脉粥样硬化发病机制以及为临床上预防和治疗动脉粥样硬化开拓一个新领域。
Atherosclerosis is a serious disease that endangers human health. The proliferation and apoptosis of vascular smooth muscle cells play a central role in the pathophysiology of Vascular Smooth Muscle Cells, which are fundamentally regulated by various oncogenes, and C-myc plays an important role Irreplaceable dual function, which affects and regulates cell growth, proliferation, differentiation, apoptosis and cell cycle progression as well as its own regulatory role in gene expression and other intracellular gene expression. To study the effect of C-myc on proliferation and apoptosis of vascular smooth muscle cells and its mechanism may shed new light on the pathogenesis of atherosclerosis and open up a new field for the prevention and treatment of atherosclerosis clinically.