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聚合酶链反应单链构象多态性和基因测序法观察脂联素基因I164T突变与中国安徽地区汉族人2型糖尿病的关系。受试者中未发现I164T突变,但在糖耐量异常组中,发现该基因的H142P新突变。提示I164T突变可能不是本组2型糖尿病的重要遗传因素,且该基因位点突变具有种族异质性。
Relationship between the I164T Mutation of Adiponectin Gene and Type 2 Diabetes Mellitus in Han Nationality in Anhui Area of China by Single - strand Conformation Polymorphism and Gene Sequencing of Polymerase Chain Reaction. No I164T mutation was found in the subjects, but in the group with impaired glucose tolerance, a new H142P mutation was found in this gene. This suggests that the I164T mutation may not be an important genetic factor for type 2 diabetes mellitus in this group, and the genetic locus mutation has racial heterogeneity.