动物试验证明,药物毒性与给药的时间有关,酒精、茶碱、类固醇、促肾上腺皮质激素及其它一些药物,对人类的毒性和疗效与给药时间明显相关,药效的昼夜节律可能特别对那些中毒与有效量比较接近的药物,关系更密切,如抗癌药物即是如此。 动物实验已证明,常用的二种抗癌药阿霉素和顺铂,其毒性与给药时间密切相关。正常组织对药物的敏感性(毒性)有昼夜节律,而肿瘤细胞则较少这 Animal experiments have shown that drug toxicity is related to the time of administration. Alcohol, theophylline, steroids, adrenocorticotropic hormone, and other drugs are obviously related to the toxicity and efficacy of human beings. The circadian rhythm of the efficacy may be particularly relevant. Those drugs that are poisoned in close proximity to effective doses are more closely related, such as anti-cancer drugs. Animal experiments have demonstrated that the toxicity of doxorubicin and cisplatin, two commonly used anticancer drugs, is closely related to the time of administration. The sensitivities (toxicity) of normal tissues have circadian rhythms while the tumor cells are less