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慢性心力衰竭(CHF)是心血管疾病主要的死亡原因。可溶性ST2(sST2)作为一种新的心脏标志物,与CHF存在相关性。ST2是炎性因子白细胞介素1受体家族的成员之一,是由过负荷的心肌细胞分泌的血清蛋白。CHF患者血清sST2水平升高,且与心力衰竭严重程度、左心室射血分数、脑钠肽等相关,对鉴别不同程度心力衰竭及其预后评估有一定临床意义,是独立预测心力衰竭患者短期病死率的强力指标。
Chronic heart failure (CHF) is the leading cause of death from cardiovascular disease. Soluble ST2 (sST2) as a new cardiac marker correlates with CHF. ST2 is a member of the inflammatory cytokine interleukin 1 receptor family and is a serum protein secreted by overloaded cardiomyocytes. CHF serum sST2 levels, and with the severity of heart failure, left ventricular ejection fraction, brain natriuretic peptide and other related to the identification of different levels of heart failure and prognosis of a certain clinical significance, independent prediction of short-term mortality in patients with heart failure Rate of strength indicators.