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巨噬细胞作为体内的高级清道夫,吞噬微生物和凋亡坏死的细胞,吸收修饰的脂蛋白微粒。生理情况下巨噬细胞的这些功能受严密的调控。病理条件下,动脉管壁巨噬细胞聚集大量胆固醇而成为泡沫细胞,从而促进动脉粥样硬化的发展。过氧化物酶体增殖体激活受体和肝X受体作为核受体超家族的转录因子,是巨噬细胞平衡的关键调控者。本综述旨在通过讨论过氧化物酶体增殖体激活受体和肝X受体对巨噬细胞作用的研究,从而加深对动脉粥样硬化发病的病理生理机制的理解,为研发新药提供新思路。
Macrophages, as advanced scavengers in the body, engulf microbes and apoptotic necrotic cells, absorbing modified lipoprotein particles. Physiological macrophages in these functions are closely regulated. Under pathological conditions, macrophages in the arterial wall accumulate large amounts of cholesterol into foam cells, thereby promoting the development of atherosclerosis. Peroxisome proliferator-activated receptors and liver X receptors, as nuclear factor superfamily transcription factors, are key regulators of macrophage balance. This review aims to deepen the understanding of the pathophysiology of atherosclerosis by discussing the effects of peroxisome proliferator-activated receptor and liver X-receptor on macrophages and to provide new ideas for the development of new drugs .