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乙二醛酶Ⅰ(Glo-1)具有将细胞毒性的甲基乙二醛(MG)转化为无毒的乳酸盐排出体外的作用,是调节糖代谢的关键酶。在正常状态下机体MG水平极低,但在疾病状态下,体内糖酵解发生异常,导致MG积累并与蛋白质反应形成晚期糖基化终产物(AGEs),前期研究表明两者与肿瘤、糖尿病、肾脏病等疾患的发生密切相关,因此通过调控Glo-1的表达来预防和治疗相关疾病,已成为目前医学研究的热点。文章就近年来对Glo-1在多种疾病中作用机制的相关研究进行综述。
Glyoxalase Ⅰ (Glo-1) has the function of converting cytotoxic methylglyoxal (MG) to non-toxic lactate and is a key enzyme for regulating glucose metabolism. Under normal conditions, the level of MG in the body is extremely low. However, in the disease state, abnormal glycolysis occurs in vivo, causing MG to accumulate and react with proteins to form advanced glycation end products (AGEs). Previous studies showed that both were associated with tumor, diabetes , Kidney disease and other diseases is closely related to the prevention and treatment of related diseases by regulating the expression of Glo-1, has become the current medical research hot spots. In this paper, we review recent studies on the mechanism of Glo-1 in various diseases.