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【目的】观察活血灵片对创伤性肢体深静脉血栓(DVT)兔血液指标的影响。【方法】将60只新西兰兔适应性喂养1周后,随机分为正常对照组、模型组、低分子肝素钙组(剂量为300 U.kg-1.d-1)和活血灵片组(剂量为0.27 g.kg-1.d-1),观察各组对创伤性肢体深静脉血栓模型兔血液流变学、血栓素B2(TXB2)、6-酮-前列腺素(6-Keto-PGF1a)及血管内皮素(ET)水平的影响。【结果】活血灵片组的全血粘度(高切)、全血粘度(中切)、全血粘度(低切)、红细胞聚集指数、红细胞变形指数、刚性指数显著降低,与模型组比较差异均有统计学意义(P<0.05或P<0.01),血浆TXB2、ET、6-Keto-PGF1a水平显著降低,与模型组比较差异均有统计学意义(P<0.05)。【结论】活血灵片治疗DVT的作用与其能改善血液流变学指标和降低TXB2、ET、6-Keto-PGF1a水平有关。
【Objective】 To observe the effect of Huoxueling tablets on blood indexes in rabbits with traumatic limb deep venous thrombosis (DVT). 【Methods】 Sixty New Zealand white rabbits were fed for one week, then randomly divided into normal control group, model group, low molecular weight heparin group (300 U.kg-1.d-1) and Huoxue-ling tablets The dose of 0.27 g.kg-1.d-1), and observed the changes of blood rheology, TXB2, 6-Keto-PGF1a in rabbits with traumatic limb deep venous thrombosis ) And endothelin (ET) levels. 【Results】 The results of whole blood viscosity (high shear), whole blood viscosity (whole cut), whole blood viscosity (low shear), erythrocyte aggregation index, erythrocyte deformability index and rigidity index of Huoxueling tablet group were significantly lower than those of model group (P <0.05 or P <0.01). The plasma levels of TXB2, ET and 6-Keto-PGF1a were significantly lower than those in the model group (P <0.05). 【Conclusion】 The therapeutic effect of Huoxueling tablets on DVT is related to the improvement of hemorrheological indexes and the reduction of TXB2, ET and 6-Keto-PGF1a levels.