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目的:观察曲美他嗪治疗伴发糖尿病的心绞痛的效果。方法:将72例心绞痛伴糖尿病患者随机分为Ⅰ、Ⅱ两组,各36例。Ⅰ组加用曲美他嗪20 m g,Ⅱ组加用维生素C 0.1g,3次/d口服。治疗4个月观察临床症状,评价其疗效。结果:Ⅰ组治疗后每周心绞痛发作次数与硝酸甘油的用量减少,心绞痛持续时间缩短,较Ⅱ组差异有统计学意义(t=4.19~10.28,P<0.01)。Ⅰ组治疗后心肌缺血范围缩小、程度减轻,平板运动耐量提高,较Ⅱ组差异有统计学意义(t=5.43~9.79,P<0.01)。治疗后,两组血压均无明显变化。结论:曲美他嗪能够明显改善心绞痛伴糖尿病患者的心肌缺血。
Objective: To observe the effect of trimetazidine in the treatment of angina pectoris associated with diabetes. Methods: 72 patients with angina pectoris and diabetes mellitus were randomly divided into Ⅰ and Ⅱ groups, 36 cases in each group. Group Ⅰ with trimetazidine 20 m g, group Ⅱ plus vitamin C 0.1g, 3 times / d orally. Treatment of 4 months to observe the clinical symptoms, evaluate its efficacy. Results: The number of angina pectoris, nitroglycerin and angina pectoris in group Ⅰ were shorter than those in group Ⅱ (t = 4.19-10.28, P <0.01). After treatment, the extent of myocardial ischemia reduced, the degree of platelet ischemia increased, and the treadmill exercise tolerance increased. The difference was statistically significant (P <0.01). After treatment, there was no significant change in blood pressure between the two groups. Conclusion: Trimetazidine can significantly improve myocardial ischemia in patients with angina pectoris and diabetes mellitus.