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核酸疫苗 ( DNA疫苗 )能够有效地刺激机体的特异性免疫应答已经成为共识。鉴于乙型肝炎病毒核心抗原 ( HBc Ag)是机体细胞毒性 T细胞 ( CTL )识别和攻击 HBV感染肝细胞的主要靶抗原 ,我们构建了 HBc Ag核酸疫苗 ,并已观察到该核酸疫苗经不同接种方法免疫不同品系小鼠均可引起特
It has become the consensus that nucleic acid vaccines (DNA vaccines) can effectively stimulate the body’s specific immune response. Since hepatitis B virus core antigen (HBcAg) is the main target antigen for the recognition and attack of HBV-infected hepatocytes by cytotoxic T lymphocytes (CTLs), we constructed the HBcAg nucleic acid vaccine and observed that the vaccine was vaccinated with different vaccines Methods Immunization of different strains of mice can cause special