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目的:探讨比较托吡酯与卡马西平治疗部分性癫痫的临床疗效。方法:选取2012年月1月至2014年12月我科收治的部分性癫痫患者共200例作为研究对象,随机分为卡马西平组(n=100)和托吡酯组(n=100)。观察两组患者临床疗效及不良反应发生情况。结果:托吡酯组的治疗总有效率和不良反应发生率分别为93.0%和21.0%,卡马西平组分别为80.0%和42.0%,与卡马西平组相比,托吡酯组治疗总有效率显著提高,不良反应发生率显著降低,比较都有统计学差异(P均<0.05)。结论:托吡酯治疗部分性癫痫疗效可靠,不良反应少,明显优于卡马西平,临床上值得进一步研究。
Objective: To investigate the clinical efficacy of topiramate and carbamazepine in the treatment of partial epilepsy. Methods: A total of 200 patients with partial epilepsy who were admitted to our department from January 2012 to December 2014 were selected and randomly divided into carbamazepine group (n = 100) and topiramate group (n = 100). The clinical efficacy and adverse reactions of the two groups were observed. Results: The total effective rate and the incidence of adverse reactions in topiramate group were 93.0% and 21.0%, respectively. The carbamazepine group was 80.0% and 42.0% respectively. Compared with carbamazepine group, the total effective rate of topiramate group was significantly increased , The incidence of adverse reactions was significantly reduced, compared with statistical differences (all P <0.05). Conclusion: Topiramate is effective in treating partial epilepsy and has few side effects. It is superior to carbamazepine in clinic and deserves further study.