论文部分内容阅读
辅酶B_(12),作为自由基载体,能促进分子内重排反应的进行。一般认为辅酶B_(12)在重排反应过程中Co—C键的均裂是整个酶催化反应的关键步骤,而Co—C键的强弱与轴向脱氧腺苷基及其对位的轴向有机碱的电子效应和立体效应密切相关.深入研究辅酶B_(12)及其模型化合物Co—C键强的影响因素对于认识辅酶B_(12)的作用机制有重要意义.目前大部分有关辅酶B_(12)模型化合物的工作都是以钴Schiff碱为母体,轴向烷基为配体作模型化合物.本文以有
Coenzyme B_ (12), as a free radical carrier, can promote the intramolecular rearrangement reaction. It is generally believed that the cleavage of the Co-C bond during the rearrangement of coenzyme B_ (12) is the key step in the whole enzymatic reaction. The strength of the Co-C bond is not related to the axial deoxyadenosine group and its para axis Which is closely related to the electronic effect and the stereoscopic effect of organic bases.Depth research on the influencing factors of the Co-C bond strength of coenzyme B 12 and its model compounds is of great significance for understanding the mechanism of coenzyme B 12.At present, The work of model compounds B_ (12) both takes cobalt Schiff base as matrix and axial alkyl as ligand as model compounds.