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目的对比分析不同种类抗癫痫药物(antiepileptic drugs,AEDs)对伴中央—颞区棘波儿童良性癫痫(benign childhood epilepsy with centro-temporal spikes,BECT)治疗的疗效及不良反应,从而探讨其药物治疗选择的可行性。方法选择2005年10月至2012年10月在河南省人民医院儿科门诊确诊的190例BECT患儿,按照初次或添加抗癫痫药物种类进行分组,定期进行随访,统计分析服用不同种类药物之间的差异性。结果统计分析后发现拉莫三嗪(LTG)组不良反应发生率为15.69%,比左乙拉西坦(LEV)、奥卡西平(OXC)、丙戊酸钠(VPA)组的8.33%、11.11%、13.51%增多。在总有效率的对比上,OXC(87.04%)与VPA(64.86%)组、LEV(89.58%)与VPA组、LTG(84.31%)与VPA组,组间疗效具有统计学意义(P<0.05)。结论通过对比研究发现OXC、LEV治疗BECTs疗效显著、安全性高、不良反应少,OXC、LEV可作为BECTs首选的AEDs。
Objective To compare and analyze the curative effects and adverse reactions of different types of antiepileptic drugs (AEDs) on benign childhood epilepsy with centro-temporal spikes (BECT), and to explore its drug treatment options Feasibility. Methods Totally 190 cases of BECT diagnosed in pediatric outpatient department of Henan Provincial People’s Hospital from October 2005 to October 2012 were divided into groups according to the initial or added anti-epileptic drugs, followed up regularly, and the statistical analysis was made between the different types of drugs difference. Results Statistical analysis showed that the incidence of adverse reactions was 15.69% in LTM group, 8.33% in LEV, OXC and VPA groups, 11.11% and 13.51% respectively. In the total effective rate, the curative effect between OXC group (87.04%) and VPA group (64.86%), LEV (89.58%) and VPA group, LTG (84.31%) and VPA group was statistically significant (P <0.05 ). Conclusions The comparative study found that OXC and LEV have significant curative effect on BECTs, high safety and few adverse reactions. OXC and LEV can be the first choice AEDs for BECTs.