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目的通过对神经副肿瘤综合征(NPS)病例的临床特点进行归纳分析,旨在为原发肿瘤的早期诊断提供思路。方法回顾性分析18例NPS患者的临床资料,并与12例非癌性神经-肌肉病变患者的临床资料进行比较。结果大多数NPS发生于肿瘤确诊之前,原发肿瘤以肺癌为最常见,Lambert-Eaton肌无力综合征是最多见的临床类型,临床症状不能用单一病灶解释,抗核抗体检测普遍阴性,免疫治疗疗效差。结论神经-肌肉病变不能用单一病灶解释、抗核抗体检测阴性和免疫治疗疗效差是临床诊断NPS的重要依据,也是进一步筛查机体潜在恶性肿瘤的依据。
Objective To summarize the clinical features of patients with neurological paraneoplastic syndrome (NPS), and to provide ideas for the early diagnosis of primary tumors. Methods The clinical data of 18 patients with NPS were retrospectively analyzed and compared with the clinical data of 12 patients with non-cancerous neuromuscular diseases. Results Most NPS occurred before tumor diagnosis. Lung cancer was the most common primary tumor. Lambert-Eaton myasthenia syndrome was the most common clinical type. Clinical symptoms could not be explained by a single lesion, and anti-nuclear antibody test was generally negative. Immunotherapy Poor efficacy. Conclusion Neuro-muscular lesions can not be explained by a single lesion. The negative results of antinuclear antibody tests and poor immunotherapy are important evidences for clinical diagnosis of NPS. They are also the basis for further screening of potential malignant tumors in the body.