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1887年在英国上市的拿非那西丁,造成了2000多人严重的肾损害,500多人死亡,但直到1953年才逐渐认识到其不良反应并引起了人们的警觉。1998年底,美国150家医院提供的39项研究报告得出的结论,即使是按照医生要求的正常用量、用法来服药,美国每年仍然会有200多万病人由于发生不良反应导致病情恶化。而在我国现有5000万残疾人中1/3是听力残疾,其中约60%—80%的致聋原因与使用过氨基糖甙类抗生素有关。
Finasteride, marketed in the UK in 1887, caused more than 2000 severe kidney damage and more than 500 deaths. However, it was not until 1953 that people gradually noticed their adverse reactions and aroused people’s vigilance. By the end of 1998, the findings of 39 studies provided by 150 hospitals in the United States reached the conclusion that more than 2 million patients in the United States will still get worse due to adverse reactions every year, even if their dosage is used according to their normal requirements. In China, 50% of the existing 50 million people with disabilities have hearing disabilities, of which about 60% -80% of deafness causes are related to the use of aminoglycoside antibiotics.