[目的]探讨摩罗丹联合维生素E对慢性萎缩性胃炎伴低级别上皮内瘤变的临床疗效。[方法]将120例慢性萎缩性胃炎伴低级别上皮内瘤变患者随机分成2组,A组60例予摩罗丹加维生素E治疗,B组60例仅给予维生素E治疗,2组均连续服药6个月,观察2组治疗前后的临床症状、内镜及病理形态学的变化情况。[结果]A组的临床症状缓解率是90.7%、内镜下表现好转率是87.1%、对低级别上皮内瘤变的总有效率是77.7%,B组分别是69.1%、63.7%、54.6%,2组比较均差异有统计学意义(P<0.01)。[结论]摩罗丹联合维生素E治疗慢性萎缩性胃炎伴低级别上皮内瘤变临床疗效显著。 [Objective] To investigate the clinical efficacy of combination therapy with morotan and vitamin E on chronic atrophic gastritis with low grade intraepithelial neoplasia. [Methods] A total of 120 patients with chronic atrophic gastritis and low grade intraepithelial neoplasia were randomly divided into 2 groups: 60 cases in group A were treated with morotan and vitamin E; 60 cases in group B were given vitamin E only; Six months later, the clinical symptoms, endoscopic and histopathological changes of the two groups were observed before and after treatment. [Results] The remission rate of clinical symptoms in group A was 90.7%, the rate of improvement in endoscopy was 87.1%, the total effective rate in low-grade intraepithelial neoplasia was 77.7%, that of group B was 69.1%, 63.7% and 54.6 %, Two groups were statistically significant differences (P <0.01). [Conclusion] The combination of morotan and vitamin E in the treatment of chronic atrophic gastritis with low grade intraepithelial neoplasia has a significant clinical effect.